Abstract #1540

Cerebral Blood Flow and Cerebrovascular Reactivity in Acute and Chronic HIV-Infection Treated by Combination Antiretroviral Therapies

Kyle Murray¹, Md. Nasir Uddin², Madalina Tivarus³, Arun Venkataraman¹, Yuchuan Zhuang⁴, Xing Qiu⁵, Lu Wang⁵, Meera Singh⁶, Jianhui Zhong^1,3, Sanjay Maggirwar⁷, and Giovanni Schifitto^2,3

¹Physics and Astronomy, University of Rochester, Webster, NY, United States, ²Neurology, University of Rochester, Rochester, NY, United States, ³Imaging Sciences, University of Rochester, Rochester, NY, United States, ⁴Electrical and Computer Engineering, University of Rochester, Rochester, NY, United States, ⁵Biostatistics and Computational Biology, University of Rochester, Rochester, NY, United States, ⁶Microbiology and Immunology, University of Rochester, Rochester, NY, United States, ⁷Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington DC, DC, United States

Combination antiretroviral therapy (cART) maintains virologic control in HIV patients, but may lead to neurotoxicity. By using neuroimaging and cellular microparticle quantification, we explore the effects cART may have in both acute and chronic HIV-infection. We find that cART treatment does reduce microparticle levels associated with neuroinflammation to those of controls. Further, microparticle levels and neuroimaging results strengthen assumptions about immune dysfunction in HIV infection. We demonstrate that cerebral blood flow and cerebrovascular reactivity can be used in conjunction with quantitative microparticle levels to study the effects of neuroinflammation and cART treatment in both acute and chronic HIV infection.

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