Abstract #1541

Temporal progression patterns of brain atrophy in CBS and PSP determined using Subtype and Stage Inference

Yuya Saito^1,2, Koji Kamagata², Christina Andica², Wataru Uchida^1,2, Syo Murata², Akifumi Hagiwara², Toshiaki Akashi², Akihiko Wada², Masaaki Hori³, and Shigeki Aoki²

¹Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan, ²Department of Radiology, Graduate School of Medicine, Juntendo University, Tokyo, Japan, ³Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan

Corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP) are two classic clinical syndromes derived from 4 microtubule-binding domain-repeat tau pathology. However, their clinical diagnosis remains challenging due overlaps in their motor symptoms. While majority of previous studies have assessed brain volumes using cross-sectional data, the present study utilizes Subtype and Stage Inference (SuStaIn) for brain volumes based on cross-sectional brain structural magnetic resonance imaging to identify the differences in temporal brain atrophy progression patterns between CBS and PSP. Our results suggested the utility of SuStaIn for estimating brain atrophy progression patterns in and discriminating between patients with CBS and PSP.

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