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Abstract #1542

Different iron deposition patterns in hemodialysis patients with and without restless legs syndrome on MRI-QSM

Hao Wang1, Zhenchang Wang1, and Zhili on Xie2
1Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China, 2GE Healthecare, MR Research China, Beijing, Beijing, China, Beijing, China

Based on gradient echo (GRE) magnetic resonance phase data, quantitative susceptibility mapping (QSM) is a novel technology which allows the noninvasive assessment of magnetic tissue susceptibility distribution in hemodialysis (HD) patients. And iron deficiency in gray matter nuclei has been reported to lead to idiopathic restless legs syndrome (RLS) symptoms. In this study, we investigated the differences of iron deposition patterns between HD-RLS and HD-nRLS patients scanned at 3T. Compared with HD-nRLS patients, HD-RLS patients demonstrated reduced susceptibility in caudate nucleus and puteman. Hence, QSM can be used for HD-RLS diagnosis and intervention.

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