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Abstract #1543

Nucleus Accumbens Deep Brain Stimulation Ameliorated Cognitive Impairment in Metabolic Syndrome Animal Model

Ting-Chieh Chen1, Yu-Chun Lo2, Szu-Yi Chou2, Ssu-Ju Li1, Ting-Chun Lin1, Ching-Wen Chang1, Yin-Chieh Liu1, Hsin-Tzu Lu1, and You-Yin Chen1,2
1Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan, 2Ph.D. Program for Neural Regenerative Medicine, Taipei Medical University, Taipei, Taiwan

Cognitive dysfunctions were demonstrated to be associated with the metabolic syndrome (MetS), which could be treated with deep brain stimulation (DBS) of nucleus accumbens (NAc) by altering brain circuitss and facilitating synapse plasticity. However, NAc-DBS for memory-related cognitive function has yet to be investigated. Diļ¬€usion MRI, resting-state functional MRI, and behavioral test were applied in this study. We found restoration of the microstructure, increased functional connectivity, and an improvement in cognitive behaviors after NAc-DBS in the MetS models, C-C motif ligand 5/Regulated-on-Activation-Normal-T-cell-Expressed-and-Secreted knockout mice.

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