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Abstract #1592

FDG-PET imaging shows mesiotemporal hypometabolism in MRI-negative temporal lobe epilepsy

Ben A Duffy1, Julia Pia Simon1, Yan Li2, Arthur W Toga1, Wolfgang G Muhlhofer3, Robert C Knowlton2, and Hosung Kim1
1USC Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States, 2UCSF Weill Institute for Neurosciences, San Francisco, CA, United States, 3University of Alabama at Birmingham, Birmingham, AL, United States

The pathophysiology of MRI-negative temporal lobe epilepsy is not well understood. Here, we used a surface-based approach for investigating metabolic changes in the subregions of mesiotemporal structures for MRI-negative TLE patients. We found significant hypometabolism in the anterior to the intermediate hippocampus, the intermediate entorhinal cortex and the centro-medial and laterobasal amygdala. In patients with poor outcome, metabolism tended to be more interhemispherically symmetric in all three regions compared to those with good outcome, which suggests a more complicated seizure origin in this subtype of the disorder.

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