Silent cerebral infarcts are the most common neurologic injury in patients with sickle cell disease (SCD). In this study, we compared T2 -relaxation under spin tagging (TRUST) and susceptibility-based oximetry (SBO) techniques in a cohort of SCD patients compared to healthy control subjects. We observed opposite trends in oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) in SCD patients compared to controls using TRUST and SBO methods. High OEF measured by TRUST technique lead to very high supraphysiologic CMRO2 values. We conclude that SBO method is more reliable in measuring OEF and CMRO2 in patients with SCD.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords