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Abstract #1650

Whole-Brain Brain Oxygen Metabolism in Adult Sickle-Cell Patients Using Two Different Quantitative MRI Approaches

Seyed Ali Nabavizadeh1, Sanjeev Chawla1, Pei-Hsin Wu1, Ana Rodriguez-Soto2, Erin Englund2, Michael C Langham1, Farzana Sayani1, Eric Russell1, and Felix W Wehrli1
1University of Pennsylvania, Philadelphia, PA, United States, 2University of California San Diego, La Jolla, CA, United States

Silent cerebral infarcts are the most common neurologic injury in patients with sickle cell disease (SCD). In this study, we compared T2 -relaxation under spin tagging (TRUST) and susceptibility-based oximetry (SBO) techniques in a cohort of SCD patients compared to healthy control subjects. We observed opposite trends in oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) in SCD patients compared to controls using TRUST and SBO methods. High OEF measured by TRUST technique lead to very high supraphysiologic CMRO2 values. We conclude that SBO method is more reliable in measuring OEF and CMRO2 in patients with SCD.

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