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Abstract #1710

Time-efficient method for detecting subtle blood-brain barrier leakage – a clinical feasibility study

Paulien H.M. Voorter1,2, Marieke van den Kerkhof2,3, Daniëlle B.P. Eekers4, Richard A.M. Canters4, Wouter van Elmpt4, Joost J. de Jong2,3, Lisanne P.W. Canjels2,3,5, Jacobus F.A. Jansen2,3,5, Alida A. Postma2, and Walter H. Backes2,3
1Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 2Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, 3School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands, 4Department of Radiation Oncology (MAASTRO), GROW – School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, Netherlands, 5Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands

Blood-brain barrier (BBB) disruption underlies the origin of many brain disorders. Measuring subtle BBB leakage of gadolinium-based contrast agents is commonly performed by a continuous and time-consuming dynamic MRI protocol. However, BBB leakage is subtle, for which discrete sampling at strategic time-points might be sufficient. This study explores the feasibility of the time-efficient interleaved protocol by applying it to brain tumor patients. We were able to measure high permeability in a craniopharyngioma and low permeability in a low-grade tumor and in healthy tissue. The time-efficient protocol is promising and will be further evaluated in more patients.

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