Abstract #1710

Time-efficient method for detecting subtle blood-brain barrier leakage – a clinical feasibility study

Paulien H.M. Voorter^1,2, Marieke van den Kerkhof^2,3, Daniëlle B.P. Eekers⁴, Richard A.M. Canters⁴, Wouter van Elmpt⁴, Joost J. de Jong^2,3, Lisanne P.W. Canjels^2,3,5, Jacobus F.A. Jansen^2,3,5, Alida A. Postma², and Walter H. Backes^2,3

¹Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, ²Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, ³School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands, ⁴Department of Radiation Oncology (MAASTRO), GROW – School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, Netherlands, ⁵Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands

Blood-brain barrier (BBB) disruption underlies the origin of many brain disorders. Measuring subtle BBB leakage of gadolinium-based contrast agents is commonly performed by a continuous and time-consuming dynamic MRI protocol. However, BBB leakage is subtle, for which discrete sampling at strategic time-points might be sufficient. This study explores the feasibility of the time-efficient interleaved protocol by applying it to brain tumor patients. We were able to measure high permeability in a craniopharyngioma and low permeability in a low-grade tumor and in healthy tissue. The time-efficient protocol is promising and will be further evaluated in more patients.

This abstract and the presentation materials are available to members only; a login is required.

Join Here