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Abstract #1771

Improved combination of multi-inversion time images for fluid and white matter suppression

Dzung L Pham1, Neville Gai2, Yi-Yu Chou3, Abbey Goodyear2, Wen-Tung Wang3, and John A. Butman2
1Center for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation, Bethesda, MD, United States, 2National Institutes of Health, Bethesda, MD, United States, 3Henry M. Jackson Foundation, Bethesda, MD, United States

Fluid and White Matter Suppression (FLAWS) MRI uses two inversion times within a T1-weighted magnetization-prepared gradient echo sequence to enhance visualization of gray matter structures within the brain. FLAWS is based on the MP2RAGE sequence, but with different inversion times, followed by a voxel-wise minimum. In this work, we demonstrate that a variation of the regularized, ratio combination approach of MP2RAGE yields superior gray matter contrast-to-noise and intensity uniformity compared to the originally proposed FLAWS MRI combination based on minimum intensity.

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