Abstract #1773

Imaging the Nigrosome 1 using Susceptibility Weighted Imaging and Quantitative Susceptibility Mapping: An Application to Parkinson’s Disease

Zenghui Cheng¹, Naying He¹, Pei Huang², Sean K. Sethi³, Kiran Kumar Yerramsetty⁴, Vinay Kumar Palutla⁴, Weibo Chen⁵, Shengdi Chen², Fuhua Yan¹, and E.Mark Haacke^1,3,6

¹Radiology, Ruijin Hospital, school of medicine, Shanghai Jiaotong University, Shanghai, China, ²neurology, Ruijin Hospital, school of medicine, Shanghai Jiaotong University, Shanghai, China, ³Magnetic Resonance Innovations, Inc, Bingham Farms, MI, United States, ⁴MR Medical Imaging Innovations India Pvt. Ltd, Telangana, India, ⁵Philips Healthcare, Shanghai, China, ⁶Radiology, Wayne State University, Detroit, MI, United States

Imaging the nigrosome 1 has been reported to be promising in the diagnosis of Parkinson’s disease (PD), however, there is no uniform imaging protocol. This study was designed to create a rapid imaging protocol with high image quality to consistently visualize and characterize the N1 and to evaluate the loss of N1 in the diagnosis of PD. We found that the N1 sign could be consistently visualized using true SWI (tSWI) with a resolution of at least 0.67 x 0.67 x 1.34 mm³and could be seen in 95% of HCs, while only 21.1% in PD and atypical parkinsonian syndromes.

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