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Abstract #1773

Imaging the Nigrosome 1  using Susceptibility Weighted Imaging and Quantitative Susceptibility Mapping: An Application to Parkinson’s Disease 

Zenghui Cheng1, Naying He1, Pei Huang2, Sean K. Sethi3, Kiran Kumar Yerramsetty4, Vinay Kumar Palutla4, Weibo Chen5, Shengdi Chen2, Fuhua Yan1, and E.Mark Haacke1,3,6
1Radiology, Ruijin Hospital, school of medicine, Shanghai Jiaotong University, Shanghai, China, 2neurology, Ruijin Hospital, school of medicine, Shanghai Jiaotong University, Shanghai, China, 3Magnetic Resonance Innovations, Inc, Bingham Farms, MI, United States, 4MR Medical Imaging Innovations India Pvt. Ltd, Telangana, India, 5Philips Healthcare, Shanghai, China, 6Radiology, Wayne State University, Detroit, MI, United States

Imaging the nigrosome 1 has been reported to be promising in the diagnosis of Parkinson’s disease (PD), however, there is no uniform imaging protocol. This study was designed to create a rapid imaging protocol with high image quality to consistently visualize and characterize the N1 and to evaluate the loss of N1 in the diagnosis of PD. We found that the N1 sign could be consistently visualized using true SWI (tSWI) with a resolution of at least 0.67 x 0.67 x 1.34 mm3 and could be seen in 95% of HCs, while only 21.1% in PD and atypical parkinsonian syndromes.

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