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Abstract #1824

Viscerotoxic Brain Infarcts: A Voxel-Based Neuroanatomic Localization Study

Ken Chang1, James Brown2, Praveer Singh1, Jay Patel1, Katharina Hoebel1, Andrew Beers3, Bruce Rosen1, Jayashree Kalpathy-Cramer1, and Hakan Ay1
1Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2University of Lincoln, Lincoln, United Kingdom, 3University of Washington, Seattle, WA, United States

It is currently not fully known what parts of the human brain predispose to neurogenic organ injury when injured. In this study, we aimed to identify the neuroanatomic correlates of a broad range of cardiac and systemic alterations occurring after ischemic stroke. Using a mapping technique that is free from the bias of a-priori hypothesis as to any specific location, we show that both cardiac and systemic abnormalities occurring after stroke map to specific infarct locations on diffusion-weighted MR. We show that these maps are predictive of the abnormalities as well as patient outcomes.

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