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Abstract #1849

Brain GABA levels distinguish multiple sclerosis and neuromyelitis optica using edited magnetic resonance spectroscopy

fei gao1, fuxin ren1, weibo chen2, and guangbin wang1
1Shandong Medical Imaging Research Institute, Shandong University, Jinan, China, 2Philips Healthcare, shanghai, China

Distinguishing relapsing-remitting multiple sclerosis (RRMS) and neuromyelitis optica (NMO) is clinically important because they differ in prognosis and treatment. Edited magnetic resonance spectroscopy (MRS), using the MEGA-PRESS sequence, is the most widely used technique for detecting GABA in the human brain. However, none of the existing studies are performed to compare the brain GABA levels between patients with MS and NMO. In this study, we found GABA levels diļ¬€erences in the LHC and PCC between the RRMS and NMO patients, which may be helpful in distinguishing RRMS from NMO after further validation.

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