10 healthy volunteers underwent rest and stress Free-breathing myocardial native T1 mapping CMR scanning twice in a 3.0T MR scanner in midventricular short-axis position using a custom-made MRI-compatible ergometer pedal exerciser. It was demonstrated that T1 reactivity (ΔT1 values) had a moderate reliability and an excellent repeatability. The assessment of native myocardial T1 value using the pedal exerciser CMR stress/rest T1 mapping holds promise for myocardium ischemia detection without injecting gadolinium contrast agents and pharmacologic agents, also shows an excellent repeatability to demonstrates for the first time that normal myocardium has distinctive ranges of T1 reactivity to exercise stress.
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