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Abstract #2066

Correlation between changes in cardiac iron and hepatic iron in pediatric patients with thalassemia major

Antonella Meloni1, Maddalena Casale2,3, Aldo Filosa2, Laura Pistoia1, Vincenzo Positano1, Emanuele Grassedonio4, Elda Chiara Resta5, Gennaro Restaino6, Riccardo Righi7, Lorella Pitrolo8, Antonella Quarta9, and Alessia Pepe1
1MRI Unit, Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy, 2Azienda Ospedaliera di Rilievo Nazionale "A. Cardarelli", Napoli, Italy, 3Università degli Studi della Campania Luigi Vanvitelli, Napoli, Italy, 4Policlinico "Paolo Giaccone", Palermo, Italy, 5Ospedale “SS. Annunziata”, Taranto, Italy, 6Fondazione di Ricerca e Cura "Giovanni Paolo II", Campobasso, Italy, 7Ospedale del Delta, Lagosanto (FE), Italy, 8Ospedale "V. Cervello", Palermo, Italy, 9Ospedale "A. Perrino", Brindisi, Italy

In pediatric thalassemia major patients who performed a baseline and a follow-up MRI study at 18±3 months the percentage changes in global heart T2* values per month were not influenced by initial hepatic iron levels and were not correlated to final hepatic iron. Moreover, the correlation between % changes in global heart T2* and MRI liver iron concentration values did not reach the statistical significance So, our data seem not supporting the hypothesis for which it is necessary to clean the liver before removing iron from the heart.

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