Abstract #2066

Correlation between changes in cardiac iron and hepatic iron in pediatric patients with thalassemia major

Antonella Meloni¹, Maddalena Casale^2,3, Aldo Filosa², Laura Pistoia¹, Vincenzo Positano¹, Emanuele Grassedonio⁴, Elda Chiara Resta⁵, Gennaro Restaino⁶, Riccardo Righi⁷, Lorella Pitrolo⁸, Antonella Quarta⁹, and Alessia Pepe¹

¹MRI Unit, Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy, ²Azienda Ospedaliera di Rilievo Nazionale "A. Cardarelli", Napoli, Italy, ³Università degli Studi della Campania Luigi Vanvitelli, Napoli, Italy, ⁴Policlinico "Paolo Giaccone", Palermo, Italy, ⁵Ospedale “SS. Annunziata”, Taranto, Italy, ⁶Fondazione di Ricerca e Cura "Giovanni Paolo II", Campobasso, Italy, ⁷Ospedale del Delta, Lagosanto (FE), Italy, ⁸Ospedale "V. Cervello", Palermo, Italy, ⁹Ospedale "A. Perrino", Brindisi, Italy

In pediatric thalassemia major patients who performed a baseline and a follow-up MRI study at 18±3 months the percentage changes in global heart T2* values per month were not influenced by initial hepatic iron levels and were not correlated to final hepatic iron. Moreover, the correlation between % changes in global heart T2* and MRI liver iron concentration values did not reach the statistical significance So, our data seem not supporting the hypothesis for which it is necessary to clean the liver before removing iron from the heart.

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