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Abstract #2086

Evaluation of Inhomogeneous Magnetization Transfer ihMT at 9.4T for the visualization of the Purkinje Network in the heart

Kylian Haliot1,2,3, Andreea Hertanu4, Olivier Girard4, Lucas Soustelle4, Guillaume Duhamel4, Julie Magat1,2,3, and Bruno Quesson1,2,3
1IHU Liryc, Fondation Bordeaux Université, Pessac, France, 2U1045 CRCTB, Université de Bordeaux, Bordeaux, France, 3INSERM, CRCTB, U1045, Bordeaux, France, 4Aix-Marseille Univ, CNRS, CRMBM, Marseille, France

The Purkinje network (PN) of the heart plays a major role in cardiac electrical diseases such as in sudden cardiac death. Imaging of this fine network is of central interest to better characterize the links between electrical disorders and structural modifications of the heart. PN is composed of fibers containing cardiomyocytes surrounded by a collagen sheath (PF). In this study, we implemented inhomogeneous magnetization transfer (ihMT) sequence at 9.4T and evaluate this technique on ex vivo samples of pig heart fixed into formalin. We show that ihMT is a suitable candidate to increase the contrast between PF and cardiac muscle.

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