In clinical setting, there are three distinguishable entities presented mainly with left ventricular cardiac hypertrophy, including HCM, HHP and CA. Imaging differential diagnosis relies on LGE-CMR, and recently proposed native T1 mapping, which has high diagnostic accuracy and is potentially more sensitive for detecting disease than LGE imaging. However, both modalities are insufficient robustness for the differential diagnosis of three diseases. In this study, radiomics analysis was adopted into the differential diagnosis of cardiac hypertrophy with MR T1-mapping. And diagnostic accuracy of 0.95/0.96 can be achieved with test dataset, which is significantly improved as compared with conventional native T1 mapping.