The arterial input function (AIF) describes the contrast agent input to the myocardium and is required for blood flow quantification. However, the impact of the AIF sampling location on quantification by cardiovascular magnetic resonance and the diagnosis of coronary artery disease (CAD) has yet to be determined. In this study, perfusion imaging was performed in patients with suspected CAD and blood flow was quantified for seven different locations. It was found that the sampling location has a significant impact on blood flow measurements, while the ascending aorta led to the most accurate prediction of inducible perfusion abnormalities.
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