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Abstract #2277

Noninvasive Pressure Measurements in the Transverse Sinuses using ICOSA6 4DFlow – an In Vitro Validation with Catheter-based Manometry

Henrik Haraldsson1, Keerthi Valluru1, Megan Ballweber1, Ning Jin2, Sinyeob Ahn3, Evan Kao1, David Saloner1,4, and Matthew Amans1
1University of California, San Francisco, San Francisco, CA, United States, 2Siemens Healthcare, Chicago, IL, United States, 3Siemens Healthcare, San Francisco, CA, United States, 4Veterans Affairs Medical Center, San Francisco, CA, United States

Idiopathic intracranial hypertension is a condition of elevated intracranial cerebrospinal fluid pressure. Transverse sinus stenoses are clearly related to the pathophysiology, and catheter-based manometry is the “gold standard” to assess pressure gradients across these stenoses. The aim of this work is to evaluate the feasibility of assessing these pressure gradients in the intracranial veins using 4DFlow with ICOSA6 motion encoding – which also account for turbulence - and to compare these pressure gradients with catheter-based manometry. Pressure gradient were measured in patient specific phantoms using both 4DFlow and catheter-based manometry. The pressure gradient assessed showed good agreement when accounting for turbulence.

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