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Abstract #2278

A novel, accurate and robust three-dimensional quantification of circulation using finite-element methods in 4D Flow MRI data of thoracic aorta

Julio Sotelo1,2,3, Malenka M Bissell4, Yaxin Jiang4, Hernan Mella1,2,3, Joaquin Mura3,5, and Sergio Uribe1,3,6,7
1Biomedical Imaging Center, Pontificia Universidad Catolica de Chile, Santiago, Chile, 2Department of Electrical Engineering, Pontificia Universidad Catolica de Chile, Santiago, Chile, 3Millennium Nucleus for Cardiovascular Magnetic Resonance, Santiago, Chile, 4Department of Biomedical Imaging Science, Leeds Institute to Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom, 5Department of Mechanical Engineering, Universidad Técnica Federico Santa María, Santiago, Chile, 6Department of Radiology, Pontificia Universidad Catolica de Chile, Santiago, Chile, 7Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Catolica de Chile, Santiago, Chile

The circulation is normally analyzed in a 2D cross-section of the aorta, manually placed. To avoid this problem, evaluate and validate a new methodology based on Finite Elements (FE) to calculate the circulation in three-dimensions, in in-silico models, and in the ascending aorta of a group of volunteers and patients. In in-silico experiment we obtain an RMSE of the circulation values less than 1.6e-6. We also found that significant differences exist between volunteers and patients with a p-value of 0.0283. Our method is straight forward to calculate, accurate and robust throughout different resolutions and noise levels.

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