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Abstract #2502

Whole-liver apparent diffusion coefficient histogram analysis for the diagnosis and staging of liver fibrosis

Zheng You1,2, Lei Jun-qiang2, and Xu Yong-sheng2
1First Clinical Medical College of LanZhou University, Lanzhou, Gansu, China, 2Radiology, First Hospital of LanZhou University, Lanzhou, Gansu, China

This study aimed to determine whether whole-liver apparent diffusion coefficient (ADC) histogram parameters can contribute to hepatic fibrosis staging. We evaluated quantitative histogram parameters between different pathological fibrosis stages. And the diagnostic performance of ADC histogram parameters in discriminating stage 1 or greater (≥F1), stage 2 or greater (≥F2), and stage 3 or greater (≥F3) liver fibrosis were compared. The results showed that many histogram parameters (kurtosis, skewness, entropy, mode, 75th and 90th percentiles) had statistical significance among the pathologic liver fibrosis stages (P<0.05), and kurtosis yielded the highest area under the curve (0.801).

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