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Abstract #2504

Free-Breathing, Confounder-Corrected T1 Mapping in the Liver with 3D Radial Inversion Recovery MRI

Yavuz Muslu1,2, Steven Kecskemeti2,3, Diego Hernando1,2,4, and Scott B. Reeder1,2,4,5,6
1Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 2Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3Waisman Center, University of Wisconsin-Madison, Madison, WI, United States, 4Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 5Department of Medicine, University of Wisconsin-Madison, Madison, WI, United States, 6Department of Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

Quantitative T1 mapping in the liver is an emerging biomarker of hepatic fibrosis and characterization of liver function. Existing T1 mapping methods in abdomen are generally sensitive to tissue fat and B1 inhomogeneities , both of which confound estimates of T1. Further, Cartesian methods may suffer from motion related ghosting artifacts. In this work, we propose to combine 3D-radial inversion recovery with chemical shift encoded imaging to jointly estimate T1 of water, T1 of fat, proton density fat fraction (PDFF), and B0 and B1 inhomogeneities. The feasibility and performance of the proposed method are evaluated with simulations, and phantom experiments.

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