Abstract #2504

Free-Breathing, Confounder-Corrected T1 Mapping in the Liver with 3D Radial Inversion Recovery MRI

Yavuz Muslu^1,2, Steven Kecskemeti^2,3, Diego Hernando^1,2,4, and Scott B. Reeder^1,2,4,5,6

¹Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ²Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Waisman Center, University of Wisconsin-Madison, Madison, WI, United States, ⁴Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ⁵Department of Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁶Department of Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

Quantitative T₁ mapping in the liver is an emerging biomarker of hepatic fibrosis and characterization of liver function. Existing T₁ mapping methods in abdomen are generally sensitive to tissue fat and B1 inhomogeneities , both of which confound estimates of T₁. Further, Cartesian methods may suffer from motion related ghosting artifacts. In this work, we propose to combine 3D-radial inversion recovery with chemical shift encoded imaging to jointly estimate T₁ of water, T₁ of fat, proton density fat fraction (PDFF), and B₀ and B₁ inhomogeneities. The feasibility and performance of the proposed method are evaluated with simulations, and phantom experiments.

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