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Abstract #2505

Assessment of fibrosis grades in chronic liver disease using liver heterogeneity and nodularity quantification program

Tae-Hoon Kim1, Ji Eon Kim1, Jong-Hyun Ryu1, SeungJin Kim2, Min-Gi Pak2, Chang-Won Jeong1, and Kwon-Ha Yoon1,3
1Medical Convergence Research Center, Wonkwang University, Iksan, Korea, Republic of, 2Medical Science, Wonkwang University, Iksan, Korea, Republic of, 3Radiology, Wonkwang University, Iksan, Korea, Republic of

Liver fibrosis is a hallmark of chronic liver disease (CLD) characterized by the excessive accumulation of extracellular matrix proteins. To diagnose and grade the liver fibrosis, liver biopsy is the reference standard, however the method has some limitations, including potential pain, sampling variability, and low patient acceptance. Therefore, there have been efforts to develop noninvasive imaging techniques and quantification softwares for diagnosis, staging, and monitoring of liver fibrosis. This study developed a MRI-suitable quantification program for assessing heterogeneity and nodularity in the liver and compared the difference between fibrosis grades in CLD.

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