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Abstract #2878

Elliptical Localization with Pulsed Second-Order fields (ECLIPSE) for Lactate and BHB Edited Human Brain Proton MRSI

Chathura Kumaragamage1, Henk M De Feyter1, Peter B Brown1, Scott McIntyre1, Terence W Nixon1, and Robin A de Graaf1
1Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States

Βeta-hydroxybutyrate (BHB) and lactate (Lac) are MRS visible metabolites important for brain energy metabolism. In this work we investigate the feasibility to detect elevated levels of BHB with proton MRSI following oral consumption of an energy drink containing 25g of a keto-ester. A gradient-modulated ECLIPSE-OVS method with minimal chemical shift displacement was implemented for lactate and BHB edited MRSI of the human brain. Elevated levels of BHB following oral intake of a keto-ester energy drink were observed in an 8 mL nominal volume MRSI acquired within 9-min at 4 T.

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