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Abstract #2879

ECLIPSE utilizing Gradient Modulated Offset-Independent Adiabaticity (GOIA) Pulses for Human Brain Proton MRSI

Chathura Kumaragamage1, Henk M De Feyter1, Peter B Brown1, Scott McIntyre1, Terence W Nixon1, and Robin A de Graaf1
1Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States

At high magnetic field strengths (≥3T), the utility of MRSI is impeded by challenges such as increased B1 field heterogeneity, increased RF power requirements for reduced chemical shift displacement errors (CSDE), and water/lipid contamination. In this work, the utilization of gradient modulated (GOIA) RF pulses, is investigated, with elliptical localization with pulsed second order fields (ECLIPSE) for MRSI. A 15 kHz GOIA pulse based ECLIPSE double-spin-echo MRSI sequence was developed. In vivo data demonstrate that the GOIA based MRSI method provides full-intensity metabolite spectra in edge of the brain voxels, and undetectable extracranial lipid signals within or outside the brain.

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