Abstract #2897

MODIFIED HERCULES MULTI-METABOLITE EDITING with SEMI-LASER LOCALIZATION at 3T

Steve CN Hui^1,2, Muhammad G Saleh^1,2, Georg Oeltzschner^1,2, Mark Mikkelsen^1,2, Sofie Tapper^1,2, and Richard AE Edden^1,2

¹Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

An improved editing scheme was proposed for the Hadamard Editing Resolves Chemicals Using Linear-combination Estimation of Spectra (HERCULES). The original editing pulse at 4.18 ppm was replaced by a new wider-band pulse at 4.04 ppm to facilitate signal acquisition for aspartate, ascorbate and lactate. Furthermore, the new scheme (HERCULES-2) was implemented within the semi-LASER and PRESS sequences. HERCULES-2 with semi-LASER yielded increases in overall signal intensities in most targeted metabolites, robust to B₁ inhomogeneity, facilitating the precise quantification of edited spectra.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.