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Abstract #2897

MODIFIED HERCULES MULTI-METABOLITE EDITING with SEMI-LASER LOCALIZATION at 3T

Steve CN Hui1,2, Muhammad G Saleh1,2, Georg Oeltzschner1,2, Mark Mikkelsen1,2, Sofie Tapper1,2, and Richard AE Edden1,2
1Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

An improved editing scheme was proposed for the Hadamard Editing Resolves Chemicals Using Linear-combination Estimation of Spectra (HERCULES). The original editing pulse at 4.18 ppm was replaced by a new wider-band pulse at 4.04 ppm to facilitate signal acquisition for aspartate, ascorbate and lactate. Furthermore, the new scheme (HERCULES-2) was implemented within the semi-LASER and PRESS sequences. HERCULES-2 with semi-LASER yielded increases in overall signal intensities in most targeted metabolites, robust to B1 inhomogeneity, facilitating the precise quantification of edited spectra.

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