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Abstract #2914

Over-discretized reconstruction to correct for B0 inhomogeneity and improve localization in 1H-MRSI of the prostate

Carlijn Tenbergen1, Loreen Ruhm2, Arend Heerschap1, Anke Henning2,3, and Tom Scheenen1
1Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, Netherlands, 2High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 3Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States

In in vivo MRSI spatial inhomogeneities of the main magnetic field cause spectral line broadening and location dependent frequency shifts in the spectra. An over-discretized reconstruction method is applied to existing prostate 1H-MRSI data, consisting of spatial over-discretization of the MRSI grid, frequency shift correction according to a high resolution B0map and weighted spatial averaging to the target resolution. Intravoxel B0 variations are corrected for and resampling to a new target resolution results in improved localization of signals. This could lead to detection of signals with lower spectral intensity and to improved visualization of smaller cancer lesions in the prostate.

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