In in vivo MRSI spatial inhomogeneities of the main magnetic field cause spectral line broadening and location dependent frequency shifts in the spectra. An over-discretized reconstruction method is applied to existing prostate 1H-MRSI data, consisting of spatial over-discretization of the MRSI grid, frequency shift correction according to a high resolution B0map and weighted spatial averaging to the target resolution. Intravoxel B0 variations are corrected for and resampling to a new target resolution results in improved localization of signals. This could lead to detection of signals with lower spectral intensity and to improved visualization of smaller cancer lesions in the prostate.
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