Heart failure in diabetes is the leading cause of mortality in patients. Many studies show cardiac dysfunction in the STZ-induced diabetes model, however variability in cardiac metabolism and function is observed due to differences in the method of model induction. This study investigated both a high and a low dose STZ-induced diabetic model, with STZ injected in both the fasted and postprandial states. Different metabolic and functional severities were observed; with the high-dose STZ-induced diabetic model injected in the fasted state resulting in the most severe form of diabetes with remodelling of both cardiac function and metabolism.
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