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Abstract #3005

Hyperpolarized MRI Evaluation of Streptozotocin Injection in the Fasted or Postprandial State: A Metabolic and Functional Study of Diabetes

Dragana Savic1, Vicky Ball1, Carolyn Carr1, Lisa Heather1, and Damian J Tyler1
1University of Oxford, Oxford, United Kingdom

Heart failure in diabetes is the leading cause of mortality in patients. Many studies show cardiac dysfunction in the STZ-induced diabetes model, however variability in cardiac metabolism and function is observed due to differences in the method of model induction. This study investigated both a high and a low dose STZ-induced diabetic model, with STZ injected in both the fasted and postprandial states. Different metabolic and functional severities were observed; with the high-dose STZ-induced diabetic model injected in the fasted state resulting in the most severe form of diabetes with remodelling of both cardiac function and metabolism.

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