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Abstract #3024

Feasibility of Hyperpolarized [89Y]-Labeled Substrates for In Vivo Studies

Jun Chen1, Richard Martin1, Lloyd Lumata2, Zoltan Kovacs1, and Jae Mo Park1,3
1AIRC, UT Southwestern Medical Center at Dallas, Dallas, TX, United States, 2Physics, University of Texas at Dallas, Richardson, TX, United States, 3Electrical Engineering, University of Texas at Dallas, Richardson, TX, United States

Yttrium-89 in the form of diamagnetic 89Y complexes is an attractive nucleus for the design of responsive magnetic resonance spectroscopy and imaging probes the 89Y NMR chemical shift is quite sensitive to the coordination environment of the Y3+ ion. 89Y has a great potential for in vivo hyperpolarized NMR due to its extremely long T1 relaxation time. In this study, we developed an RF coil for imaging 89Y signal in vivo, tested it with phantoms containing thermally polarized and hyperpolarized yttrium compounds, and demonstrated the feasibility of using hyperpolarized 89Y complexes for in vivo studies in a rat.

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