Abstract #3024

Feasibility of Hyperpolarized [89Y]-Labeled Substrates for In Vivo Studies

Jun Chen¹, Richard Martin¹, Lloyd Lumata², Zoltan Kovacs¹, and Jae Mo Park^1,3

¹AIRC, UT Southwestern Medical Center at Dallas, Dallas, TX, United States, ²Physics, University of Texas at Dallas, Richardson, TX, United States, ³Electrical Engineering, University of Texas at Dallas, Richardson, TX, United States

Yttrium-89 in the form of diamagnetic ⁸⁹Y complexes is an attractive nucleus for the design of responsive magnetic resonance spectroscopy and imaging probes the ⁸⁹Y NMR chemical shift is quite sensitive to the coordination environment of the Y³⁺ ion. ⁸⁹Y has a great potential for in vivo hyperpolarized NMR due to its extremely long T¹ relaxation time. In this study, we developed an RF coil for imaging ⁸⁹Y signal in vivo, tested it with phantoms containing thermally polarized and hyperpolarized yttrium compounds, and demonstrated the feasibility of using hyperpolarized ⁸⁹Y complexes for in vivo studies in a rat.

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