Meeting Banner
Abstract #3025

Detecting early response to immune checkpoint inhibitors by multimodal molecular imaging

Yu Saida1, Shun Kishimoto1, Yasunori Otowa1, Kazutoshi Yamamoto1, Jeffery R. Brender1, Nallathamby Devasahayam1, and Murali C. Krishna1
1National Cancer Institute, Bethesda, MD, United States

The purpose of this study is to detect physiologic and metabolic changes in tumor-bearing mouse model in response to immune checkpoint blockade therapy by using multi-modal imaging methods including hyperpolarized 13C-MRI with [1-13C] pyruvate, with [1,4-13C2] fumarate, and DCE-MRI. Lactate/Pyruvate ratio tended to decrease in αPD-L1 Ab + αCTLA-4 Ab treated tumor in mouse model although not statistically significant. Significantly increased Malate/Fumarate ratio and higher permeability were observed in treated tumor. We will investigate capability of detecting early response to immune checkpoint blockade therapy using multi-modal imaging.

This abstract and the presentation materials are available to 2020 meeting attendees and eLibrary customers only; a login is required.

Join Here