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Abstract #3088

Volumetric CEST May Provide Insight into Clinical Neuroprotection Stratification in Sub-Acute Ischaemic Stroke

Alex K Smith1, Davide Carone2, James Garrard2, Michael A Chappell1,3, Peter Jezzard1, and James Kennedy2
1Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom, 2Acute Vascular Imaging Centre, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, 3Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, United Kingdom

Understanding the contributions of secondary injury following ischaemic stroke is critical for developing post-stroke neuroprotective strategies. Nuclear Overhauser effect (NOE) CEST and MT are techniques sensitive to aliphatic compounds and macromolecules, respectively, and which may point to intracellular microstructural integrity post-ischaemia, potentially helping stratification of patients for further treatment. We show that rapid 3D volumetric measurements at clinical MRI strength in patients demonstrate significant reductions in relative NOE ratio and MT exchange rate, both within conventionally defined areas of infarction using ADC, and in areas in which ADC is insensitive (infarct growth). Further work is required to confirm this observation.

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