Abstract #3178

Local Structure Orientation (LSO) for histology-based validation of MRI: evaluation in a physical phantom study

Wadha Alyami^1,2, Andre Kyme³, and Roger Bourne¹

¹Medical Imaging Sciences, Faculty of Health Sciences, University of Sydney, Sydney, Australia, ²Medical imaging sciences, King Saud University, Riyadh, Saudi Arabia, ³Biomedical Engineering, School of Aerospace Mechanical & Mechatronic Engineering, Faculty of Engineering and IT, University of Sydney, Sydney, Australia

Histology-based validation of magnetic resonance imaging (MRI) is essential to confirm imaging technique specificity and accuracy. One-to-one correspondence is complicated by histological preparation and differences in MRI and histology contrast mechanisms. A new approach, based on local structure orientation (LSO) and using microstructural features, is proposed. LSO facilitates registration based on direct correspondence between tissue fibre structure to emulate a common contrast mechanism. Using a physical phantom derived from a chicken heart with embedded fibrous structures, residual displacement was 14.1 mm for advanced mean squares (AMS), 2.2 mm for modified AMS (AMSR), and 3.3 mm for mutual information (MI).

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