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Abstract #3178

Local Structure Orientation (LSO) for histology-based validation of MRI: evaluation in a physical phantom study

Wadha Alyami1,2, Andre Kyme3, and Roger Bourne1
1Medical Imaging Sciences, Faculty of Health Sciences, University of Sydney, Sydney, Australia, 2Medical imaging sciences, King Saud University, Riyadh, Saudi Arabia, 3Biomedical Engineering, School of Aerospace Mechanical & Mechatronic Engineering, Faculty of Engineering and IT, University of Sydney, Sydney, Australia

Histology-based validation of magnetic resonance imaging (MRI) is essential to confirm imaging technique specificity and accuracy. One-to-one correspondence is complicated by histological preparation and differences in MRI and histology contrast mechanisms. A new approach, based on local structure orientation (LSO) and using microstructural features, is proposed. LSO facilitates registration based on direct correspondence between tissue fibre structure to emulate a common contrast mechanism. Using a physical phantom derived from a chicken heart with embedded fibrous structures, residual displacement was 14.1 mm for advanced mean squares (AMS), 2.2 mm for modified AMS (AMSR), and 3.3 mm for mutual information (MI).

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