Abstract #3213

Increased susceptibility in cortical veins and nuclei in small vessel disease revealed by susceptibility weighted imaging and mapping at 7T

Yue Wu^1,2,3, Qingle Kong^1,2,3, Chen Ling⁴, Chengyue Sun⁴, Jing An⁵, Rong Xue^1,2,3, Yan Zhuo^1,2,3, Qi Yang⁶, Yun Yuan⁴, and Zihao Zhang^1,2,3

¹State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, ²University of Chinese Academy of Sciences, Beijing, China, ³CAS Center for Excellence in Brain Science and Intelligence Technology, Beijing, China, ⁴Department of Neurology, Peking University First Hospital, Beijing, China, ⁵Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, ⁶Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary cerebral small vessel disease (SVD). This study aimed to use susceptibility weighted imaging and mapping (SWIM) at 7 Tesla to evaluate venous oxygen saturation (SvO₂) and subcortical nuclear iron deposition and explore the correlation of these parameters with the clinical phenotypes of CADASIL patients. We found decreases in SvO₂ and abnormal iron deposition in patients compared with healthy individuals. Also, we found associations between susceptibilities and clinical characteristics of CADASIL. These results suggest that SWIM can be used to assess clinical conditions of SVD patients.

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