Meeting Banner
Abstract #3213

Increased susceptibility in cortical veins and nuclei in small vessel disease revealed by susceptibility weighted imaging and mapping at 7T

Yue Wu1,2,3, Qingle Kong1,2,3, Chen Ling4, Chengyue Sun4, Jing An5, Rong Xue1,2,3, Yan Zhuo1,2,3, Qi Yang6, Yun Yuan4, and Zihao Zhang1,2,3
1State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 2University of Chinese Academy of Sciences, Beijing, China, 3CAS Center for Excellence in Brain Science and Intelligence Technology, Beijing, China, 4Department of Neurology, Peking University First Hospital, Beijing, China, 5Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, 6Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary cerebral small vessel disease (SVD). This study aimed to use susceptibility weighted imaging and mapping (SWIM) at 7 Tesla to evaluate venous oxygen saturation (SvO2) and subcortical nuclear iron deposition and explore the correlation of these parameters with the clinical phenotypes of CADASIL patients. We found decreases in SvO2 and abnormal iron deposition in patients compared with healthy individuals. Also, we found associations between susceptibilities and clinical characteristics of CADASIL. These results suggest that SWIM can be used to assess clinical conditions of SVD patients.

This abstract and the presentation materials are available to 2020 meeting attendees and eLibrary customers only; a login is required.

Join Here