GRAPPA reconstructed images may exhibit noise modulated by the receiver coil sensitivities. Total variation (TV) regularization has been recently used to solve the image de-noising problem. However, conventional TV fails to remove staircase artifacts in the reconstructed MR images due to inhomogeneities in field strength and receiver coils. In this abstract, total generalized variation (TGV) regularization is used to de-noise the GRAPPA reconstructed images, while eliminating the limitations posed by TV. Experiments are performed on 8-channel in-vivo human-head data set. The results show that the proposed method successfully removes the noise and preserve fine details in the GRAPPA reconstructed images.