Abstract #3781

Simultaneous B1- and Fat-Corrected T1 Mapping Using Chemical-Shift Encoded MRI

Nathan Tibbitts Roberts^1,2, Diego Hernando^1,2,3,4, Timothy Colgan¹, Daiki Tamada¹, and Scott B Reeder^1,3,4,5,6

¹Radiology, University of Wisconsin - Madison, Madison, WI, United States, ²Electrical and Computer Engineering, University of Wisconsin - Madison, Madison, WI, United States, ³Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ⁴Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, ⁵Medicine, University of Wisconsin - Madison, Madison, WI, United States, ⁶Emergency Medicine, University of Wisconsin - Madison, Madison, WI, United States

Spatially varying B1 inhomogeneities and tissue fat are known confounders of quantitative T1 mapping methods that use variable flip angle techniques. Separately acquired B1 calibration maps can be used to correct flip angle errors caused by B1 inhomogeneities, but this requires an additional acquisition. In this work we propose a novel approach for simultaneous estimation of B1, T1, proton density fat-fraction and R2* using dual orthogonal RF pulses and multiple flip angles. The feasibility and noise performance of this proposed acquisition and fitting strategy are evaluated using Cramer-Rao Lower Bound analysis, simulations, and preliminary phantom experiments.

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