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Abstract #3820

Temporal SNR in multiecho fMRI and its dependence on the choice of weights

Thomas Liu1, Bochao Li2, Conan Chen1, Brice Fernandez3, Baolian Yang4, and Suchandrima Banerjee5
1Center for Functional MRI, UC San Diego, La Jolla, CA, United States, 2Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, 3GE Healthcare, Buc, France, 4GE Healthcare, Waukesha, WI, United States, 5GE Healthcare, Menlo Park, CA, United States

In multi-echo fMRI, data from multiple echoes are combined using weights. We use the framework of the generalized Rayleigh quotient (GRQ) to derive the optimal weights for temporal SNR (tSNR) and multi-echo tSNR (metSNR) measures of performance. We also examine the sensitivity of both these measures to the choice of weights. We find that metSNR measures are relatively insensitive to the weights in gray matter regions as compared to tSNR measures, which show greater sensitivity in these regions. We interpret the findings using the form of the GRQ.

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