Abstract #3820

Temporal SNR in multiecho fMRI and its dependence on the choice of weights

Thomas Liu¹, Bochao Li², Conan Chen¹, Brice Fernandez³, Baolian Yang⁴, and Suchandrima Banerjee⁵

¹Center for Functional MRI, UC San Diego, La Jolla, CA, United States, ²Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, ³GE Healthcare, Buc, France, ⁴GE Healthcare, Waukesha, WI, United States, ⁵GE Healthcare, Menlo Park, CA, United States

In multi-echo fMRI, data from multiple echoes are combined using weights. We use the framework of the generalized Rayleigh quotient (GRQ) to derive the optimal weights for temporal SNR (tSNR) and multi-echo tSNR (metSNR) measures of performance. We also examine the sensitivity of both these measures to the choice of weights. We find that metSNR measures are relatively insensitive to the weights in gray matter regions as compared to tSNR measures, which show greater sensitivity in these regions. We interpret the findings using the form of the GRQ.

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