Abstract #3832

Characterization of regional differences in cerebral vascular response to breath holding using BOLD fMRI

Hui-Chieh Yang¹, Tsai-Ying Liao², Guan-Jie Wang³, Chun-Ming Chen⁴, and Shin-Lei Peng³

¹Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan, ²School of Medicine, China Medical University, Taichung, Taiwan, ³Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan, ⁴Department of Radiology, China Medical University Hospital, Taichung, Taiwan

Previous studies have demonstrated that cerebrovascular reactivity (CVR) depends on the baseline vascular dilation status between groups. Within the brain, there also exist spatial variations in resting cerebral blood flow (CBF) and CVR across different cerebral regions; however, the relationship between regional CBF and CVR remains unclear. We found the frontal lobe had the maximal resting CBF but the minimal vascular response to hypercapnia, whereas the occipital lobe had the lowest rest CBF but the maximal reactivity to hypercapnia, suggesting that there is a small and a large autoregulatory efficiency at high and low resting CBF in the brain, respectively.

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