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Abstract #3832

Characterization of regional differences in cerebral vascular response to breath holding using BOLD fMRI

Hui-Chieh Yang1, Tsai-Ying Liao2, Guan-Jie Wang3, Chun-Ming Chen4, and Shin-Lei Peng3
1Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan, 2School of Medicine, China Medical University, Taichung, Taiwan, 3Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan, 4Department of Radiology, China Medical University Hospital, Taichung, Taiwan

Previous studies have demonstrated that cerebrovascular reactivity (CVR) depends on the baseline vascular dilation status between groups. Within the brain, there also exist spatial variations in resting cerebral blood flow (CBF) and CVR across different cerebral regions; however, the relationship between regional CBF and CVR remains unclear. We found the frontal lobe had the maximal resting CBF but the minimal vascular response to hypercapnia, whereas the occipital lobe had the lowest rest CBF but the maximal reactivity to hypercapnia, suggesting that there is a small and a large autoregulatory efficiency at high and low resting CBF in the brain, respectively.

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