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Abstract #3833

30-day Reliability Assessments between Cortisol, Vigilance and Brain Activity

Yu-Lun Su1, Hong-Yi Wu2, Po-Yi Chen2, Chi-Yun Liu1, Ai-Ling Hsu3, Yi-Ping Chao4, and Changwei Wesley Wu5
1Taipei Medical University, Taipei, Taiwan, 2National Taiwan University, Taipei, Taiwan, 3Quanta Computer Inc., Taoyuan, Taiwan, 4Chang Gung University, Taoyuan, Taiwan, 5Graduate Institute of Mind, Brain and Consciousness, Taipei Medical University, Taipei, Taiwan

To estimate the reliability of task-fMRI, we conducted a repeated measure fMRI study of psychomotor vigilance task once per day and 30 days in total. Salivary cortisol and sleep duration were taken into consideration based on previous study. However, we found dramatic within-subject variability in the brain activity of dACC and primary motor cortex. The cortisol showed insignificant association with brain activity, but sleep duration affected the motor and temporal cortices. Such finding suggests that the PVT-based fMRI showed large variability across different days, which might be associated with the deviations of sleep duration.

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