Abstract #3834

CBF alteration in human obesity: An arterial spin labeling study

Guan-Jie Wang¹, Chun-Ming Chen², and Shin-Lei Peng¹

¹Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan, ²Department of Radiology, China Medical University Hospital, Taichung, Taiwan

Obesity is accompanied with damage to several organs including the brain. Although an extensive body of neuroimaging literature indicates that brain structure deteriorates with obesity, little information related to the relationship between CBF and obesity is available. In this study, we investigated the potential influence of body mass index (BMI) on brain abnormalities in young adults by combining functional and structural MRI studies. Results show CBF measured with the noninvasive MRI technique decreased as the BMI increased, as manifested by altered CBF in thalamus and visual-associated areas, including Brodmann areas (BA)7, BA18, and BA19

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