Abstract #3856

Resolving Spatially Distinct Patterns of Nociception with Functional MRI at 7.0 T En Route to Pain-Specific Neurosignatures

Henning Matthias Reimann¹, Jurjen Heij¹, Joao Periquito¹, Antje Els¹, Haopeng Han¹, and Thoralf Niendorf^1,2

¹Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, ²Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

In recent years, the identification of pain-specific biomarkers has become the holy grail of pain research in the fMRI community. Painful stimuli, salient (attention capturing) non-painful stimuli, and nociceptive stimuli in analgesic subjects (who cannot feel pain) elicit similar BOLD patterns that cannot be resolved at 3T. Recognizing this shortcoming we present preliminary fMRI data at 7T (double spatial resolution), comparing painful stimuli with isosalient non-painful stimuli in healthy volunteers and an analgesic subject who is insensitive to pain. The overall goal of this study is to detail the evoked neurosignatures for pain-specificity and identify diagnostic biomarkers of pain experience.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.