Abstract #3857

Dynamic Brain-Body Coupling of Breath-by-Breath O2-CO2 Exchange Ratio with Resting State Cerebral Hemodynamic Fluctuations

Suk-tak Chan¹, Karleyton C Evans², Tian-yue Song¹, Juliette Selb¹, Andre van Kouwe¹, Bruce R Rosen¹, Yong-ping Zheng³, Andrew C Ahn¹, and Kenneth K Kwong¹

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, ²Biogen Inc., Cambridge, MA, United States, ³Biomedical Engineering, Hong Kong Polytechnic University, Kowloon, Hong Kong

We showed that the oscillations of breath-by-breath O₂-CO₂ exchange ratio (bER) were superior to those of end-tidal CO₂ in correlating with the low frequencies (0.008-0.03Hz) of resting state cerebral hemodynamic fluctuations (CHF). Brain regions showing significant association of ΔBOLD with bER overlapped with many regions of default mode network. Transcranial Doppler sonography and fMRI were used to measure CHF and time series of partial pressure of O₂ and CO₂ were collected. bER-CHF coupling is a novel metric to measure brain-body interaction that may provide some answers to the physiological contributions to low frequencies of CHF.

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