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Abstract #3858

Cerebrovascular Reactivity Assessment with O2-CO2 Exchange Ratio Under Brief Breath Hold Challenge

Suk-tak Chan1, Karleyton C Evans2, Tian-yue Song1, Juliette Selb1, Andre van Kouwe1, Bruce R Rosen1, Yong-ping Zheng3, Andrew C Ahn1, and Kenneth K Kwong1
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, 2Biogen Inc., Cambridge, MA, United States, 3Biomedical Engineering, Hong Kong Polytechnic University, Kowloon, Hong Kong

Here we tested the hypothesis that the cerebrovascular responses to brief breath hold epochs were coupled not only with increased partial pressure of carbon dioxide (PCO2), but also with decreased partial pressure of oxygen (PO2). fMRI map of cerebrovascular reactivity (CVR) to breath-by-breath O2-CO2 exchange ratio covers similar regions as map of CVR to exogenous CO2 challenge. Substantially fewer regions in fMRI map of CVR to endogenous end-tidal CO2 satisfied statistical significance. Our results support the hypothesis that hypoxia and hypercapnia work synergistically to enhance cerebrovascular responses to breath hold.

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