Abstract #3859

Cerebral hemodynamic responses of subjective cognitive decline evoked by loaded N-back tasks

Yaoyu Zhang¹, Wenying Du², Ying Han^2,3,4, and Jia-Hong Gao¹

¹Center for MRI Research, Peking University, Beijing, China, ²Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China, ³Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China, ⁴National Clinical Research Center for Geriatric Disorders, Beijing, China

Subjective cognitive decline (SCD) is a high risk for Alzheimer’s disease. Most of the existing studies made their observations during the resting state of the brain. This study compared the responses of SCD and normal controls (NC) evoked by loaded N-back tasks. A load-dependent effect is clearly seen in both groups. CBF, as compared to other parameters, shows higher sensitivity in detecting the difference between SCD and NC subjects. Our results may help understand the physiological mechanisms and develop early diagnostic strategies of SCD.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.