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Abstract #3859

Cerebral hemodynamic responses of subjective cognitive decline evoked by loaded N-back tasks

Yaoyu Zhang1, Wenying Du2, Ying Han2,3,4, and Jia-Hong Gao1
1Center for MRI Research, Peking University, Beijing, China, 2Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China, 3Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China, 4National Clinical Research Center for Geriatric Disorders, Beijing, China

Subjective cognitive decline (SCD) is a high risk for Alzheimer’s disease. Most of the existing studies made their observations during the resting state of the brain. This study compared the responses of SCD and normal controls (NC) evoked by loaded N-back tasks. A load-dependent effect is clearly seen in both groups. CBF, as compared to other parameters, shows higher sensitivity in detecting the difference between SCD and NC subjects. Our results may help understand the physiological mechanisms and develop early diagnostic strategies of SCD.

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