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Abstract #3892

Paired Sham and Active Groups Activate Different Brain Regions to the Same Feedback Signal during fMRI Neurofeedback

Seyhmus Guler1, Onur Afacan1, Alexander L. Cohen1, and Simon K. Warfield1
1Boston Children's Hospital and Harvard Medical School, Boston, MA, United States

There is growing interest in fMRI neurofeedback (fMRI-nf) to facilitate therapeutic reorganization of brain function. However, the mechanisms underlying self-regulation processes are incompletely understood. Here we interrogate the mechanisms of fMRI-nf using an experimental protocol designed to increase lateralized motor activity. Twelve right-handed healthy adults were assigned into age- and sex-matched active and sham study arms. Each participant received active or sham feedback during one scanning session. We constructed group-averaged activation maps and lateralization index. During neurofeedback, active and sham groups demonstrated different brain activation. We did not observe any long-lasting functional reorganization and improvement in lateralization index.

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