Abstract #3893

Aberrant amplitude of low frequency fluctuations of spontaneous brain activity in patients with Parkinson’s disease

Yanjun Liu¹, Mengyan Li², Xinhua Wei³, Xiuhang Ruan³, Guihe Hu², Haobo Chen², and Yaoqin Xie¹

¹Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ²Department of Neurology, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China, ³Department of Radiology, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China

Parkinson’s disease (PD) patients are widely reported with abnormalities in motor and cognitive features. Early diagnosis can be benefit if neuroimaging markers are well developed. This study investigated the altered amplitude of low frequency fluctuations (ALFF) of brain activity by functional MRI and explored the neural correlates of motor and cognitive symptoms of PD. Compared to normal controls, PD patients exhibited increased ALFF in default mode network and decreased in cerebellum. The ALFF was negatively correlated with the motor performances of PD in cerebellum. The findings suggest the cerebellum as critical area associated with motor and cognitive performances in PD.

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