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Abstract #3893

Aberrant amplitude of low frequency fluctuations of spontaneous brain activity in patients with Parkinson’s disease

Yanjun Liu1, Mengyan Li2, Xinhua Wei3, Xiuhang Ruan3, Guihe Hu2, Haobo Chen2, and Yaoqin Xie1
1Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2Department of Neurology, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China, 3Department of Radiology, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China

Parkinson’s disease (PD) patients are widely reported with abnormalities in motor and cognitive features. Early diagnosis can be benefit if neuroimaging markers are well developed. This study investigated the altered amplitude of low frequency fluctuations (ALFF) of brain activity by functional MRI and explored the neural correlates of motor and cognitive symptoms of PD. Compared to normal controls, PD patients exhibited increased ALFF in default mode network and decreased in cerebellum. The ALFF was negatively correlated with the motor performances of PD in cerebellum. The findings suggest the cerebellum as critical area associated with motor and cognitive performances in PD.

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