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Abstract #3894

Silent functional MRI for novel sound discrimination using the auditory oddball paradigm

Nikou Louise Damestani1, David John Lythgoe1, Owen O'Daly1, Florian Wiesinger1,2, Ana Beatriz Solana2, Steven Charles Rees Williams1, and Fernando Zelaya1
1Department of Neuroimaging, King's College London, London, United Kingdom, 2GE Healthcare, Munich, Germany

We present the first demonstration that a multi-echo variant of a silent fMRI pulse sequence (Looping Star) is sensitive to the BOLD response elicited by the processing of novel auditory stimuli. We employed an established event-related paradigm known as the ‘oddball’ task. Our results show remarkable consistency with a previous investigation using conventional loud fMRI with the same paradigm. We also demonstrate that Looping Star reveals activation differences between auditory challenges not visible using conventional fMRI. Additionally, between-subject correlations and differences in activation between sessions were evaluated. This study supports the use of Looping Star for studies of sound-averse populations.

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