We present the first demonstration that a multi-echo variant of a silent fMRI pulse sequence (Looping Star) is sensitive to the BOLD response elicited by the processing of novel auditory stimuli. We employed an established event-related paradigm known as the ‘oddball’ task. Our results show remarkable consistency with a previous investigation using conventional loud fMRI with the same paradigm. We also demonstrate that Looping Star reveals activation differences between auditory challenges not visible using conventional fMRI. Additionally, between-subject correlations and differences in activation between sessions were evaluated. This study supports the use of Looping Star for studies of sound-averse populations.
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