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Abstract #3895

Serum levels of inflammatory markers modulates brain structural changes and post-traumatic headache trajectory in mild traumatic brain injury 

Xuan Niu1,2, Yingxiang Sun2, Shuoqiu Gan2, Ming Zhang2, and Lijun Bai3
1Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, St.Louis, MO, United States, 2Department of Medical Imaging, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China, Xi'an, China, 3The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China, Xi'an, China

Post-traumatic headache (PTH) is one of the most frequent and persistent physical symptoms following mild traumatic brain injury (mTBI). However, the underlying neurobiological basis and modulatory component remained unclear. Evidence indicated that neuroinflammation is a major contributor in the pathogenesis of PTH. We hypothesized that the effect of peripheral inflammatory signaling on PTH could be produced by influencing brain structure that subserve pain modulatory function. Our findings demonstrated that neuroinflammation following mTBI is a potential process affecting structural changes in cognitive component of pain modulation, which may serve as a potential neurobiological mechanism underlying the emergence and persistence of PTH.

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