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Abstract #3896

Progressive gray matter atrophy and altered structural covariance network in pontine infarction

Ying Wei1, Caihong Wang1, Peifang Miao1, Luobing Wu1, Yingying Wang1, Kaiyu Wang2, and Jingliang Cheng1
1The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 2GE Healthcare, MR Research China, GE Healthcare, MR Research, Beijing, China

In order to identify longitudinal changes in gray matter volumes (GMVs) and structural covariance network after pontine infarction (PI), eleven patients and twenty normal underwent MRI scans and neurological examinations during six-month period. Changes of GMV were evaluated by using the voxel-based morphometry (VBM), and structural covariance networks were constructed. In general, the patients exhibited significant decreased GMV in bilateral cerebellum posterior lobe and extended disordered structural covariance network. In addition, the GMVs were correlated with behavior scores showing the abnormal results may be the mechanism of some impaired neurological function.

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