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Abstract #4430

Discrepancy between In-vivo Measurements and Monte-Carlo Simulations with Spherical Structures in B-tensor Encoding

Noemi G Gyori1,2, Matt G Hall2, Christopher A Clark2, Daniel C Alexander1, and Enrico Kaden1
1Centre for Medical Image Computing, University College London, London, United Kingdom, 2Great Ormond Street Institute of Child Health, University College London, London, United Kingdom

In in-vivo B-tensor encoding measurements, linear tensor encoding (LTE) and spherical tensor encoding (STE) waveforms estimate the same mean diffusivity in brain white and grey matter. Contrary to this, we show that in Monte-Carlo simulations of quasi-spherical restrictions, LTE and STE signal decay curves are markedly different and lead to different mean diffusivity estimates. We investigate this discrepancy in the presence of variable compartment sizes, geometric distortions in cell shapes, permeable cell membranes, and water exchange between connected cellular geometries. Our results suggest that a strict model of restricted diffusion may not be suitable for brain tissue.

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