In in-vivo B-tensor encoding measurements, linear tensor encoding (LTE) and spherical tensor encoding (STE) waveforms estimate the same mean diffusivity in brain white and grey matter. Contrary to this, we show that in Monte-Carlo simulations of quasi-spherical restrictions, LTE and STE signal decay curves are markedly different and lead to different mean diffusivity estimates. We investigate this discrepancy in the presence of variable compartment sizes, geometric distortions in cell shapes, permeable cell membranes, and water exchange between connected cellular geometries. Our results suggest that a strict model of restricted diffusion may not be suitable for brain tissue.
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