Abstract #4636

Alterations in brain white matter structural network in children with seizure and cognitive dysfunction

Yannan Cheng¹, Chao Jin², Xianjun Li², Congcong Liu², Miaomiao Wang², Huifang Zhao², Xiaoyu Wang², Yuli Zhang², Fan Wu², Mengxuan Li², Cong Tian², Peiyao Chen², Xiaocheng Wei³, Jianxin Guo², and Jian Yang²

¹Department of Radiology, the First Affiliated Hospital, Xi’an Jiaotong University, Xi'an, China, Xi'an, China, ²the First Affiliated Hospital, Xi’an Jiaotong University, Xi'an, China, Xi'an, China, ³MR Research China, GE Healthcare, Bei Jing, People's Republic of China, Xi'an, China

Seizures are the most common disease in children and some types like epilepsy usually cause many serious co-morbidities such as cognitive dysfunction. We detailed the alterations of brain white matter network in children with seizure and cognitive dysfunction by comparing the difference of network properties and connectivity strength between the patient and control groups. Here, we found that children with seizure and cognitive dysfunction show a suboptimal brain organization with reduced information integration ability, and abnormalities in multiple intrinsic functional connectivity may be the structural basis for cognitive impairment in patients with seizures.

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