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Abstract #4636

Alterations in brain white matter structural network in children with seizure and cognitive dysfunction

Yannan Cheng1, Chao Jin2, Xianjun Li2, Congcong Liu2, Miaomiao Wang2, Huifang Zhao2, Xiaoyu Wang2, Yuli Zhang2, Fan Wu2, Mengxuan Li2, Cong Tian2, Peiyao Chen2, Xiaocheng Wei3, Jianxin Guo2, and Jian Yang2
1Department of Radiology, the First Affiliated Hospital, Xi’an Jiaotong University, Xi'an, China, Xi'an, China, 2the First Affiliated Hospital, Xi’an Jiaotong University, Xi'an, China, Xi'an, China, 3MR Research China, GE Healthcare, Bei Jing, People's Republic of China, Xi'an, China

Seizures are the most common disease in children and some types like epilepsy usually cause many serious co-morbidities such as cognitive dysfunction. We detailed the alterations of brain white matter network in children with seizure and cognitive dysfunction by comparing the difference of network properties and connectivity strength between the patient and control groups. Here, we found that children with seizure and cognitive dysfunction show a suboptimal brain organization with reduced information integration ability, and abnormalities in multiple intrinsic functional connectivity may be the structural basis for cognitive impairment in patients with seizures.

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