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Abstract #4885

MRI and PET for staging of axillary lymph nodes in breast cancer at diagnosis

Pauline Huang1, Renee Cattell1, Meghan Moriarty1, Kwan Chen1, Lev Bangiyev1, Cliff Bernstein1, Jules Cohen1, Lea Baer1, Dinko Franceschi1, Haifang Li1, and Tim Duong1
1Radiology, Renaissance School of Medicine, Stony Brook, NY, United States

In breast cancer, lymph node status is highly related to prognosis. We evaluated the use of MRI of axillary lymph nodes (aLNs) to detect metastasis in pre-chemo breast cancer with PET as reference standard. For 4 readers scoring on T1-weighted DCE and T2-weighted MRI, the AUC, sensitivity, specificity and accuracy ranged from 0.73-0.85, 64%-83%, 54-91%, and 67-79%, respectively. Readers showed significant agreement (Spearman’s Rho 0.35-0.65). Though improvement is needed, this approach presents a less invasive method of assessing all aLNs and avoiding their unnecessary removal.

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