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Abstract #4886

q-Space imaging is more sensitive to breast tumour cellularity than conventional diffusion-weighted imaging methods at 3T

Nicholas Senn1, Yazan Masannat2, Ehab Husain3, Bernard Siow4, Steven D Heys5, and Jiabao He1
1Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, United Kingdom, 2Breast Unit, Aberdeen Royal infirmary, Aberdeen, United Kingdom, 3Pathology department, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, 4Francis Crick Institute, London, United Kingdom, 5School of Medicine, University of Aberdeen, Aberdeen, United Kingdom

q-Space imaging (QSI) was compared against conventional DWI and non-Gaussian diffusion models of diffusion kurtosis imaging (DKI) and stretched-exponential model (SEM) to evaluate the skewness in histogram distribution of diffusion displacement and diffusivity for profiling breast tumour cellularity. We investigated whole breast tumours excised from surgery, with imaging performed same day overnight on a clinical 3T MRI system. We found QSI to yield a higher effect gradient to assess cellularity in breast cancer compared with conventional diffusion-weighted imaging methods. The skewness obtained from QSI further showed fidelity with the skewness of cellularity obtained from histology.

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